N-acetylneuraminic acid (Sialic Acid): Benefits and Role in Health | CABIO

Unlock the potential of N-acetylneuraminic acid (Sialic Acid) for enhanced health and nutrition. Learn about the importance and diverse applications of sialic acid in this informative guide.

The Critical Function and Potential Applications of Sialic Acid in Infant Nutrition 

Infant nutrition solutions pioneer, CABIO Biotech (Wuhan) Co., Ltd. In this article, we will examine the fundamental properties, biological functions, health benefits, and extensive food industry applications of sialic acid. In recent years, the infant nutrition and functional food markets have paid increasing attention to sialic acid, a significant bioactive ingredient.

Section 1: Fundamental N-acetylneuraminic acid (Sialic Acid) Properties and Sources

What exactly is N-acetylneuraminic acid (Sialic Acid)? What are its chemical and structural properties?

As an important sugar-aldehyde compound, sialic acid is widespread in organisms, and its unique structure and chemical properties make it an essential component of biological systems. Sialic acid is a sugar-aldehyde derivative of twenty amino acids that is extensively distributed on the surfaces of animal and plant cells and in their body secretions. Common forms include N-acetylneuraminic acid (Sialic Acid) (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). The molecular structures of these sialic acids contain a variety of functional groups, enabling them to perform a variety of functions in organisms.  

Sialic acid is a crucial molecule for cellular recognition and signaling due to its chemical properties. They interact with cell membrane receptors and ligands to regulate intercellular interactions and signal transduction. Sialic acid is also involved in cell adhesion and migration, playing a crucial regulatory function in cell motility and tissue formation.

Sialic acid can be obtained through dietary consumption or synthesized by cells themselves. Animal tissues, dairy products, and some vegetation are the main sources of sialic acid in nature. Humans are unable to synthesize sialic acid and must therefore obtain it from diet, particularly sialic acid-rich foods, to meet physiological requirements.

As an essential bioactive molecule, sialic acid possesses complex and diverse structures and chemical properties, and performs a variety of crucial functions in living organisms. Understanding the fundamental properties and sources of sialic acid is crucial for elucidating its biological functions and potential applications, according to researchers.

What are the sialic acid's sources?

Animal tissues, dairy products, and certain vegetation are the primary natural sources of N-acetylneuraminic acid (Sialic Acid). One of the most significant sources of sialic acid is animal tissue. On the cell surfaces and in the body fluids of humans and other animals, their presence is widespread. Sialic acid, a significant sugar-aldehyde compound, is involved in a variety of biological processes, including cell recognition, signal transduction, and immune regulation.  

Additionally, dairy products are a significant source of sialic acid. N-acetylneuraminic acid (Sialic Acid) is found in large quantities in products such as milk and lactic acid beverages. To supplement neonates' physiological requirements during growth and development, infant formula frequently contains added sialic acid. The presence of sialic acid in dairy products substantially promotes infant and young child growth and immune function development.

Some organisms also contain sialic acid. Certain algae and plants contain minute quantities of sialic acid, which may be structurally distinct from sialic acid derived from animals. nana Sialic acid from plants can infiltrate the body through sustenance and provide essential nutrients.

There are numerous natural sources for sialic acid, including animal tissues, dairy products, and certain vegetation. These sources supply us with sialic acid, which is essential for maintaining normal human functions and health.

Section 2:Functions and Mechanisms of N-acetylneuraminic acid (Sialic Acid) in Biological Processes.  

What are the sialic acid's mechanisms of action in biological processes?

N-acetylneuraminic acid (Sialic Acid) plays an essential function in biological processes, and its mechanisms are involved in crucial biological processes such as cell signaling, cell adhesion, and receptor activation. nana Sialic acid is crucial for cell signaling. On cell surfaces, nana sialic acid is typically found in glycoproteins and glycolipids, forming modifications known as glycosylation. These alterations can impact intercellular interactions and signaling, modulating processes such as cell growth, differentiation, and apoptosis, and consequently influencing cell function. 

Sialic acid is also essential for cell adhesion. Cell adhesion is the interaction and adhesion between cells or between cells and the extracellular matrix, which is essential for maintaining the structure and function of tissues. By interacting with other proteins, nana sialic acid participates in adhesion between cells and between cells and matrix, thereby regulating tissue formation and maintenance.  

Sialic acid is crucial for receptor activation. It can bind to specific receptors as ligands, initiating intracellular signaling pathways and modulating the function and metabolism of cells. The biological significance of this receptor activation mechanism includes cell proliferation, differentiation, and immune response.

Notably, the structural and chemical diversity of sialic acid is the basis for its multifunctionality in cellular processes. Different forms of sialic acid can interact with a variety of ligands and receptors, resulting in distinct biological effects.

How does N-acetylneuraminic acid (Sialic Acid) influence the immune system, nervous system, and gastrointestinal health?

N-acetylneuraminic acid (Sialic Acid) serves a crucial function in the regulation of the human immune system. The immune system is the body's defense against disease and pathogens. According to scientific studies, sialic acid can affect the function and activity of immune cells and regulate immune responses. Sialic acid may reduce inflammatory responses by modulating the expression of inflammatory factors, thereby protecting the immune system from over-activation-induced injury, particularly during inflammation. 

Additionally, sialic acid has beneficial effects on the nervous system. The nervous system is the body's control center and is intimately associated with perception, cognition, and behavior. Sialic acid serves an essential role in the formation and maintenance of the nervous system. According to studies, sialic acid regulates neural conduction and information transmission by participating in the formation and connection of neurons. Therefore, the presence of sialic acid promotes the normal growth and maintenance of the nervous system.

Additionally, N-acetylneuraminic acid (Sialic Acid) improves gastrointestinal health. The stomach is a vital organ for digestion and assimilation, as well as an integral component of the immune system. According to studies, sialic acid aids in maintaining the health of the intestinal mucosa, improves intestinal barrier function, and inhibits the entry of hazardous substances. This is essential for maintaining normal digestive and immune function.

Section 3:The Importance of Sialic Acid in Infant Nutrition

What are the primary functions of sialic acid in infant brain development and immune function development?

Sialic acid is essential for the development of the brain and immune system in neonates and young children. Sialic acid is essential for fetal brain development. Early infancy is a time of rapid and critical brain development, and sialic acid plays a regulatory role in this process. It contributes to the formation of intricate neural networks by participating in the growth and connection of neural cells. These networks serve as the foundation for neonates' intellectual and cognitive development, so the role of sialic acid at this juncture is crucial. 

Sialic acid has a significant impact on the immune system development of neonates. After birth, the immune system of infants progressively matures and strengthens, and sialic acid can stimulate the production and activity of immune cells, thereby enhancing immune function. This enables neonates to defend themselves better against the invasion of external pathogens and toxic substances, thereby reducing the risk of infections and diseases. Moreover, sialic acid regulates inflammatory responses to protect the infant immune system from harm caused by over-activation.

What sialic acid requirements do expectant and nursing women have?

Women who are pregnant or nursing have an increased need for sialic acid. During pregnancy, the developing fetal brain has a high demand for sialic acid, which is also absorbed by the mother's body. Pregnant women must consume sufficient sialic acid to satisfy the requirements of the fetus and ensure healthy development. 

During lactation, mothers provide neonates with nutritional support by transferring sialic acid through breast milk. Breast milk is the best sustenance for infants because it contains an abundance of sialic acid. The presence of sialic acid in breast milk is crucial for cerebral development and immune function in neonates. To fulfill the nutritional requirements of the neonate, lactating women must consume sufficient sialic acid.

Section 4:Applications of Sialic Acid in Functional Foods and Health Products

What functions does sialic acid serve in functional foods and health products?

There are numerous applications for sialic acid in functional foods and health products. It provides unique nutritional and functional support for these products. As an essential nutrient, sialic acid is commonly added to functional foods and health products to boost nutritional value and functional effects.

Sialic acid is frequently added as a nutritional supplement to functional foods. Since sialic acid plays a crucial role in infant brain development and immune function development, the addition of sialic acid to functional foods can promote intellectual development and boost immunity. In addition, sialic acid has anti-inflammatory and antioxidant properties that reduce cell injury caused by free radicals and protect cell health.

In the sphere of health products, sialic acid is frequently employed as an antioxidant and immune modulator. nana Sialic acid can neutralize harmful free radicals, delay the aging of cells, and prevent oxidative injury to the body. Additionally, sialic acid can modulate immune system function, improve disease resistance, and lower the risk of infection. 

In addition, the use of sialic acid in foods such as dairy products, baked goods, and health beverages is acquiring popularity. Adding sialic acid to dairy products can increase nutritional value and product competitiveness. In baked goods, sialic acid can improve functionality and enhance consumer appeal. In health drinks, sialic acid improves health benefits and satisfies contemporary demands for nutritious foods.

Section 5: Safety and stability of sialic acid during food processing  

How well does sialic acid withstand food processing?

An essential factor to consider is the stability of sialic acid during food processing. Different temperatures, pH levels, and processing conditions can all affect the stability of sialic acid during food processing. Consequently, systematic research is required to ensure that sialic acid retains its nutritional value and functional properties throughout food processing.

It is crucial to investigate the stability of sialic acid under diverse temperature conditions. Different temperatures may have an effect on the structure and properties of sialic acid, so it is necessary to determine the optimal stability conditions. 

Also required is consideration of sialic acid stability under varying pH conditions. diverse pH values may influence the molecular structure and chemical properties of sialic acid, necessitating research into its stability and adaptability under diverse pH levels.

The interactions between sialic acid and other food components must also be thoroughly examined. Sialic acid may react with other constituents during food processing, altering its functionality and stability. Therefore, research is required into the interaction mechanisms between sialic acid and other food components to assure its stability and safety.

Section 6: Potential Applications for Sialic Acid  

In the food industry, sialic acid has vast application potential, particularly in the functional food and health product markets. With increasing health and nutrition awareness, nana sialic acid has promising utilization prospects as an important bioactive component that positively impacts consumer health and well-being.

As a significant sugar-aldehyde compound, nana sialic acid plays essential roles in biological processes such as cell signaling and adhesion, making it an ideal additive for functional foods and health products seeking to increase bioactivity and functionality. 

Due to its beneficial effects on the immune system, nervous system, and gastrointestinal health,nana sialic acid has significant nutritional value. The markets for functional foods and health products are garnering consumer interest, and sialic acid as a natural and effective nutrient is gaining popularity.

In the food industry, sialic acid will become an essential development direction. Research and application of sialic acid will become more in-depth and extensive as a result of ongoing scientific and technological advances. It is anticipated that sialic acid will play an increasingly significant role in the development of functional foods and health products, providing people with healthier, safer, and higher quality food options.

CABIO Biotech (Wuhan) Co., Ltd. is devoted to the study and application of sialic acid, and has made significant advancements in neonatal nutrition and functional foods. As an essential bioactive component, sialic acid plays a crucial function in infant and young child brain and immune system development. To promote innovation and growth in the food industry, the team continues to conduct extensive research and develop sialic acid applications. 

Stability and safety during food processing are crucial considerations for sialic acid applications. Through extensive research and testing, CABIO ensures that its sialic acid products maintain outstanding quality and functionality under various food processing conditions, supplying the food processing industry with dependable nutritional and functional ingredients. In the meantime, nana sialic acid's crucial functions in the immune system, nervous system, and gastrointestinal health are well understood. The contribution to global health is priceless. Consequentially, the potential of sialic acid in the field of nutritional supplements is continuously investigated, with a commitment to developing high-quality sialic acid supplements to meet health requirements and promote the health and wellness of more people. Particularly in neonatal nutrition, sialic acid is crucial. The objective is to provide expectant women, nursing mothers, and infants with high-quality sialic acid supplements to support their healthful development. Efforts and resources will continue to be devoted to the in-depth study of sialic acid's functions and mechanisms, contributing to the healthful development of future generations. It is anticipated that sialic acid will present the food industry with additional opportunities and challenges, while also contributing positively to the health and well-being of individuals, as a result of sustained effort and collaboration. CABIO Biotech (Wuhan) Co., Ltd. will persevere in innovation and optimization to promote the application and development of sialic acid in foods, thereby contributing more to the prosperity of the industry and the health of consumers.

In conclusion, CABIO Biotech (Wuhan) Co., Ltd remains committed to the study and utilization of sialic acid, with an emphasis on its function in infant nutrition and general health. Through extensive research and development, the company intends to harness the potential of sialic acid to positively impact the health and growth of the next generation. CABIO Biotech is committed to playing a substantial role in this enthralling journey. The future of sialic acid in the food industry contains tremendous opportunities and challenges.

nana Sialic acid, a pivotal component in human nutrition, fulfills numerous vital functions essential for overall health. As a prominent sugar molecule found abundantly in various organisms, including humans, sialic acid function is instrumental in maintaining physiological balance through its multifaceted roles.

A fundamental aspect of sialic acid function lies in cellular communication and recognition. Positioned on the surfaces of cells, nana sialic acid function serves as an integral part of cell surface receptors, facilitating the transmission of signals and enabling cell identification. This critical sialic acid function underscores its significance in regulating cellular interactions and physiological processes.

Additionally, sialic acid function plays a crucial role in immune modulation, influencing the activities of immune cells and regulating immune responses. This sialic acid function is paramount for maintaining immune system equilibrium and bolstering the body's defense mechanisms against diseases.

In the realm of human nutrition, understanding sialic acid function is of utmost importance. Research indicates that comprehending sialic acid function is essential for harnessing its potential health benefits, highlighting its significance in dietary considerations. Cabio's sialic acid supplements provide a convenient means to enhance sialic acid intake, thereby supporting overall bodily functions.

nana Sialic acid function encompasses vital aspects such as cellular communication, immune modulation, and nutritional support. The diverse roles of sialic acid function underscore its importance in human physiology and emphasize the necessity of adequate intake for optimal health.


Sialic Acid: Revealing Its Crucial Role in Infant Nutrition and Future Food Applications

What is the most important enzyme in sialic acid's biosynthetic pathway? What is this enzyme's function?

The most important enzyme in the biological synthesis pathway of sialic acid is N-acetylneuraminic acid synthase. This enzyme catalyzes the formation of N-acetylneuraminic acid (Neu5Ac, also known as sialic acid) from N-acetylglucosamine and phosphoenolpyruvic acid. This is the initial phase in the biological synthesis of sialic acid and the most important regulatory point throughout the entire synthesis process.

Does sialic acid serve an essential role in the progression and genesis of disease? If so, could you provide an illustration of its mechanism of action?

Yes, sialic acid plays a significant role in the onset and progression of disease. For instance, the protein structures on the surfaces of certain viruses (such as the influenza virus) contain sialic acid binding sites, which allow the viruses to infect and penetrate host cells. Moreover, cancer cell surfaces frequently overexpress certain sialic acid types, which aids cancer cells in evading immune surveillance. Therefore, sialic acid serves an important function in the development of disease, metastasis, and treatment resistance.

What are some of the most recent technologies or techniques utilized in sialic acid research? How do these technologies affect the evaluation of sialic acid levels and food stability?

Answer: In the field of sialic acid research, liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a prevalent and efficient technique. This technique can accurately detect trace levels of sialic acid in foods and measure multiple categories of sialic acid simultaneously. In addition, high performance liquid chromatography (HPLC) has been widely used to analyze the content and composition of sialic acid. These technologies enable scientists to better comprehend the variations and stability of sialic acid in foods, thereby ensuring its functionality and efficacy.

What are the greatest obstacles facing sialic acid applications in the agricultural industry? How can these obstacles be surmounted to guarantee its effective use in foods?

Answer: Applications of sialic acid in the food industry encounter significant obstacles. Due to the complexity of its biological synthesis, sialic acid purification is expensive, limiting its use on a large scale. Secondly, sialic acid's stability may be affected by conditions such as heat, acid, and alkali during food processing and storage. To surmount these obstacles, scientists are investigating biotechnology and enzyme engineering for more cost-effective sialic acid production. In the meantime, the addition of stabilizers and regulation of food processing conditions contribute to the stability and bioactivity of sialic acid in foods.

During digestion and assimilation, are there any interactions between sialic acid and other components? Influence these interactions its bioavailability? 

Yes, the digestion and absorption of sialic acid can be impacted by other substances. Certain fibers and polyphenolic compounds in foods, for instance, can form complexes with sialic acid, thereby decreasing its solubility and bioavailability. In addition, digestive fluid components such as gastric acid and pepsin may degrade or modify the structure of sialic acid. These interactions may affect the intestinal absorption and bioactivity of sialic acid. To assure the effective delivery and utilization of sialic acid, food design and formulation must take these interactions into account.

Are there any regulatory restrictions regarding the addition of sialic acid to infant formula? What specific sialic acid usage requirements do these regulations stipulate?

Answer 6: Yes, sialic acid addition to infant formula is subject to regulatory restrictions. Regarding the nutritional components of infant formula, regulations and standards in various nations and regions may vary. Generally, the use of sialic acid must adhere to applicable food safety and nutritional standards. In addition, certain nations or regions may limit the maximum quantity of sialic acid addition to assure infant food safety and nutritional balance. In order to develop and market infant formula products, it is necessary to comply with all applicable local regulations and standards.

Exist any studies examining the effects of various food processing techniques on sialic acid levels and stability? Such as heat or chilling treatment?

Yes, there are studies examining the effects of various food processing techniques on the levels and stability of sialic acid. Some studies indicate that thermal interventions (such as boiling or high-temperature baking) can degrade some sialic acid, particularly in acidic environments. Additionally, chilling and refrigeration may impact the stability of sialic acid in foods. In order to maximize the retention of sialic acid levels and bioactivity during food processing, suitable processing methods and conditions should be selected.

Does sialic acid form complexes and/or contaminants with other food components? These complexes have an influence on the biological effects of sialic acid?

Yes, sialic acid can form complexes and additives with other food components. Sialic acid can form stable complexes with proteins, polysaccharides, and lipids, for instance. These complexes may affect sialic acid's stability, solubility, and bioavailability. In addition, the formation of complexes may also influence the biological effects of sialic acid, for instance by enhancing its absorption or release. In order to assure the efficacy and functionality of sialic acid, food designers must take into account these complex structures.  

Are there any recent findings regarding the functions of sialic acid in gastrointestinal health and microbial balance? Do these results support the addition of sialic acid to foods to improve gastrointestinal health?

Recent research has examined the function of sialic acid in gut health and microbial homeostasis, so the answer is yes. These studies demonstrate that sialic acid aids in maintaining the integrity and stability of the intestinal mucosa and promotes the proliferation of beneficial gastrointestinal microorganisms. In addition, sialic acid is believed to function as a specific receptor for certain probiotics, thereby promoting their colonization and proliferation. These findings support the addition of sialic acid to foods to promote gastrointestinal health and microbial equilibrium.

Have any investigations been conducted to engineer the biological synthesis pathway of sialic acid? Can these modifications enhance the yield and purity of sialic acid to meet the needs of the food industry? 

Yes, engineering the biological synthesis pathway of sialic acid has been investigated. Through genetic and metabolic engineering, scientists have modified the metabolic pathways of microorganisms such as yeast and lactic acid bacteria to efficiently synthesize sialic acid. These modifications have considerably increased the yield and purity of sialic acid, making it possible to meet the demands of the food industry. In addition, they have established the groundwork for the production and application of sialic acid in a sustainable manner.

  • facebook
  • Twitter
  • LinkedIn
  • Youtobe
  • Recommended reading

    How is sialic acid utilized in functional foods and nutritional supplements?

    Sialic acid is utilized extensively in functional foods and dietary supplements. It is added to improve the nutritional value and provide functional advantages. Sialic acid supplements contribute to overall health by promoting cognitive health, bolstering the immune system, and acting as antioxidants.

    What are the prospects for sialic acid in the food industry in the future?

    In the food industry, the future prospects for sialic acid are encouraging. As consumer health consciousness increases, the demand for functional foods and dietary supplements will rise. Due to its diverse biological functions, sialic acid is an ideal additive for augmenting the nutritional and functional qualities of food products. Continuous research and development are anticipated to reveal additional applications for sialic acid, providing consumers with innovative and health-improving products.

    How does sialic acid contribute to cell communication and adhesion?

    Sialic acid is essential for cell adhesion and communication. It exists as part of glycoproteins and glycolipids on the surface of cell membranes and contributes to glycosylation. This alteration affects cell-to-cell interactions and signaling pathways, thereby regulating cell proliferation, differentiation, and apoptosis, which are essential for cellular function.

    Dietary Supplements

    N-acetylneuraminic Acid
    SA, short for sialic acids, is a class of derivatives of nine-carbon monosaccharide and the generic name of a group of chemical compounds. N-acetylneuraminic acid, NANA for short, is the most common form of sialic acid. NANA is found in various biological tissues mainly in the form of cell membrane glycoprotein and glycolipid and is most concentrated in cerebrospinal fluid (CSF) and colostrum. It is also widely found in nature, especially in edible bird’s nest, milk and eggs. Studies have shown that NANA has a variety of biological functions, for example neurotransmission, brain development promotion, whitening cosmetics, probiotic growth promotion, tumor control, virus control and AD treatment, etc. 
    Dietary Supplements

    CABIO Sialic Acid

    The chemical name of sialic acid (commonly known as bird's nest acid) is N-acetylneuraminic acid. It is one of the components of human milk oligosaccharides in breast milk, and it is also the characteristic functional component of traditional high-end tonic food - bird's nest.

    Jointly developed by Wuhan Zhongke Optics Valley Green Biotechnology Co., Ltd. - a substantially owned subsidiary of CABIO - and the Chinese Academy of Sciences, CABIO’s bird's nest acid is a safe and high-quality new raw material for food as it is produced with fermentation technology. As an emerging functional ingredient, bird's nest acid has good application prospects in the fields of infant formula food, healthy food, high nutrition food and cosmetics.

    CABIO Sialic Acid